Hypoglycemic Syndrome in a Patient with Proinsulin-Only Secreting Pancreatic Adenoma (Proinsulinoma)

Insulinoma resection facilitated by the artificial endocrine pancreas.

The artificial endocrine pancreas was adapted to assist with the intraoperative localization of an insulin-secreting islet cell adenoma in a 23-year-old patient with a five-month history of hypoglycemic attacks. Glycemia was monitored in continuously withdrawn whole blood, and dextrose was infused to maintain euglycemia by an artificial endocrine pancreas with a closed loop that excluded its us...

A FSH-Secreting Pituitary Macroadenoma Causing A Testosterone Deficiency Syndrome

Appendix Insulin Secreting Neuroendocrine Tumor in a Diabetic Patient: A Challenging Diagnosis

Introduction: Tumor-induced hypoglycemia is a rare entity and it is mainly due to pancreatic insulinomas. Non-islet cell tumor hypoglycemia is really exceptional and ectopic insulin secretion has been previously suggested. Case Presentation: A 79 year-old type 2 diabetic man, after over 30 years of poorly controlled diabetes, observed an unexplained improving of glycemic control with recurrent ...

The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma.

Because of the occurrence of two polypeptide chains in the insulin molecule, it has been proposed by several investigators, most recently by Givol et al.,I that it may be synthesized in vivo as a single large polypeptide chainwhich is converted byproteolysis to insulin after the native conformation has been established. This mechanism would undoubtedly ensure correct and efficient assembly in v...

Malignant insulinoma arising from intrasplenic heterotopic pancreas.

CONTEXT Heterotopic pancreas is defined as ectopic pancreatic tissue without vascular or anatomic continuity with the normal pancreas. The spleen is a rare site of origin. This case report describes a patient with a malignant insulinoma which originated from an intrasplenic heterotopic pancreas. CASE REPORT A 46-year-old man with three previous episodes of neuroglucopenic and adrenergic sympt...